Risk factors for symptomatic and asymptomatic norovirus infection in the community

Phillips, Gemma (2010) ‘Risk factors for symptomatic and asymptomatic norovirus infection in the community’, Epidemiology & Infection, 139(11), pp. 1676-1686.

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The objective of this study was to investigate risk factors for norovirus-associated infectious intestinal disease (IID) and asymptomatic norovirus infection. Individuals with IID and healthy controls were recruited in a community-based study in England (1993–1996). This is the first risk-factor study to use viral load measurements, generated by real-time RT–PCR, to identify cases of norovirus-associated IID and asymptomatic infections. Using multivariable logistic regression the main risk factor identified for norovirus-associated IID was contact with a person with IID symptoms. Infectious contacts accounted for 54% of norovirus cases in young children and 39% of norovirus cases in older children and adults. For young children, contacts outside the household presented the highest risk ; for older children and adults, the highest risk was associated with child contacts inside the household. Foreign travel and consumption of shellfish increased the risk of norovirus-associated IID. Lifestyle and dietary factors were associated with a decreased risk of both norovirus-associated IID and asymptomatic infection. No risk factors were identified for asymptomatic norovirus infection.

Item Type: Article
Additional Information: Citation: Phillips, G., Tam, C.C., Rodrigues, L.C. and Lopman, B. (2010), 'Risk factors for symptomatic and asymptomatic norovirus infection in the community', Epidemiology & Infection, 139(11), pp. 1676-1686, doi:10.1017/S0950268810002839.
Divisions: Schools > Health, Sports and Bioscience, School of > Institute for Health and Human Development
Depositing User: Mr Stephen Grace
Date Deposited: 09 May 2012 10:45
Last Modified: 27 Sep 2012 11:59
URI: http://hdl.handle.net/10552/1592

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