New and novel uses for paracetamol

Conference paper


Ayoub, S. 2013. New and novel uses for paracetamol. UEL Research and Knowledge Exchange Conference 2013. University of East London, London 26 Jun 2013 London University of East London.
AuthorsAyoub, S.
TypeConference paper
Abstract

Paracetamol is used clinically for the treatment of pain and fever. Recent investigations in experimental animals confirmed paracetamol is able to induce potent hypothermia, which is self-reversible and does not lead to any long term toxicities. In this investigation, the authors sought to investigate the mechanism through which paracetamol induces hypothermia in experimental animals. The authors present strong scientific evidence, which demonstrate that the paracetamol-induced hypothermia is mediated through inhibition of the activity of the novel cyclooxygenase (COX) enzyme, COX-3. Further investigations confirm that the paracetamol induced hypothermia is not dependent on interactions with the endocannabinoid or transient receptor potential vanillid-1 (TRPV-1). In addition, co-administration of paracetamol with a cannabinoid agonist resulted in synergistic hypothermia. These data provide a strong rationale for the use of paracetamol along with a cannabinoid agonist for the induction of therapeutic hypothermia in the clinic. Hypothermia is induced for therapeutic purposes in critically ill patients presenting to the clinic with stroke, cardiac arrest or neurotrauma.

However, the current approaches used for the induction of therapeutic hypothermia are inefficient, slow and can only be performed in the hospital setting. Most of the neuronal damage takes place during the first hour following the development of critical illness. Having provided evidence on the mechanism of paracetamol-induced hypothermia and the fact that paracetamol and cannabinoid agonists induced synergistic hypothermia, we propose that combination therapy can be translated to the clinic for the induction of therapeutic hypothermia. The advantages that drug-induced therapeutic hypothermia offer over the currently used methods for the induction of therapeutic hypothermia include fact onset of hypothermia; within a few minutes as opposed to 30-60 minutes. This approach offers a cheap and readily available method for the induction of therapeutic hypothermia that has the potential of saving thousands of lives.

KeywordsParacetamol; hypothermia; stroke; cardiac arrest
Year2013
ConferenceUEL Research and Knowledge Exchange Conference 2013
PublisherUniversity of East London
Publisher's version
License
CC BY-ND
File
License
CC BY-ND
Publication dates
Print26 Jun 2013
Publication process dates
Deposited20 Jun 2013
Place of publicationLondon
Permalink -

https://repository.uel.ac.uk/item/85wwq

Download files

  • 310
    total views
  • 161
    total downloads
  • 8
    views this month
  • 4
    downloads this month

Export as

Related outputs

Paracetamol (acetaminophen): A familiar drug with an unexplained mechanism of action
Ayoub, S. S. 2021. Paracetamol (acetaminophen): A familiar drug with an unexplained mechanism of action. Temperature. 8 (4), pp. 351-371. https://doi.org/10.1080/23328940.2021.1886392
Effects of heparan sulfates with different structures on leukaemia cells: U937 and THP-1 cell differentiation
Bajwa, P., Garrido Mesa, N., Seed, M. and Ayoub, S. 2019. Effects of heparan sulfates with different structures on leukaemia cells: U937 and THP-1 cell differentiation. 14th World Congress on Inflammation 2019. Sydney, AU 15 - 19 Sep 2019 World Congress on Inflammation.
Sucrose octasulphate regulates the expression of M1 and M2 macrophage-specific markers in U937 monocytes
Bajwa, P., Garrido Mesa, N., Seed, M. and Ayoub, S. 2019. Sucrose octasulphate regulates the expression of M1 and M2 macrophage-specific markers in U937 monocytes. 14th World Congress on Inflammation 2019. Sydney, AU 15 - 19 Sep 2019 World Congress on Inflammation.
Loss of hypothermic and anti-pyretic action of paracetamol in cyclooxygenase-1 knockout mice is indicative of inhibition of cyclooxygenase-1 variant enzymes
Ayoub, S. and Flower, R. J. 2019. Loss of hypothermic and anti-pyretic action of paracetamol in cyclooxygenase-1 knockout mice is indicative of inhibition of cyclooxygenase-1 variant enzymes. European Journal of Pharmacology. 861 (Art. 172609). https://doi.org/10.1016/j.ejphar.2019.172609
Pharmacological targeting of the GABAʙ receptor alters Drosophila's behavioural responses to alcohol
Ranson, D., Ayoub, S., Corcoran, O. and Casalotti, S. 2019. Pharmacological targeting of the GABAʙ receptor alters Drosophila's behavioural responses to alcohol. Addiction Biology. 25 (Art. e12725). https://doi.org/10.1111/adb.12725
Role of GABAB receptors in ethanol induced behaviours
Ranson, D., Ayoub, S. and Casalotti, S. 2017. Role of GABAB receptors in ethanol induced behaviours. pA2 Online: Proceedings of the British Pharmacological Society. 18 (1).
Pharmacological Modulation of Alcohol Tolerance via GABA-B receptors in Drosophila melanogaster
Ranson, D., Ayoub, S., Corcoran, O. and Casalotti, S. 2018. Pharmacological Modulation of Alcohol Tolerance via GABA-B receptors in Drosophila melanogaster. 11th FENS Forum of Neuroscience. Berlin, Germany 07 - 11 Jul 2018
Naltrexone Reverses Ethanol Preference and Protein Kinase C Activation in Drosophila melanogaster
Koyyada, Rajeswari, Latchooman, Nilesh, Jonaitis, Julius, Ayoub, S., Corcoran, O. and Casalotti, S. 2018. Naltrexone Reverses Ethanol Preference and Protein Kinase C Activation in Drosophila melanogaster. Frontiers in Physiology. 9 (175), pp. 1-7. https://doi.org/10.3389/fphys.2018.00175
Role of gamma-aminobutyric acid-B receptors in ethanol induced behaviours
Ranson, D., Ayoub, S. and Casalotti, S. 2017. Role of gamma-aminobutyric acid-B receptors in ethanol induced behaviours. Society for the Study of Addiction Conference. Newcastle, UK 08 - 10 Nov 2017
First evidence of the conversion of paracetamol to AM404 in human cerebrospinal fluid
Sharma,, Chhaya V., Long, Jamie H., Shah, Seema, Rahman, Junia, Perrett, David, Ayoub, S. and Mehta, Vivek 2017. First evidence of the conversion of paracetamol to AM404 in human cerebrospinal fluid. Pharmacology 2017. Queen Elizabeth II Conference Centre, London, UK 11 - 13 Dec 2017
The requirement of p38-MAPKinase and peroxisome proliferator-activated receptor-g for the induction of cyclooxygenase-2 by interleukin-4 drives macrophages into an anti-inflammatory phenotype
Manoj, Sivanjaa, Morgan, W. and Ayoub, S. 2017. The requirement of p38-MAPKinase and peroxisome proliferator-activated receptor-g for the induction of cyclooxygenase-2 by interleukin-4 drives macrophages into an anti-inflammatory phenotype. Pharmacology 2017. Queen Elizabeth II Conference Centre, London, UK 11 - 13 Dec 2017
The perception of Pharmacology among undergraduate students at the University of East London
Deshai, Devyani and Ayoub, S. 2017. The perception of Pharmacology among undergraduate students at the University of East London. Pharmacology 2017. Queen Elizabeth II Conference Centre, London, UK 11 - 13 Dec 2017
First evidence of the conversion of paracetamol to AM404 in human cerebrospinal fluid
Sharma, Chhaya, Long, Jamie H, Shah, Seema, Rahman, Junia, Perrett, David, Ayoub, S. and Mehta, Vivek 2017. First evidence of the conversion of paracetamol to AM404 in human cerebrospinal fluid. Journal of Pain Research. 10, pp. 2703-2709. https://doi.org/10.2147/JPR.S143500
Construction of cell models for drug-receptor pharmacology activities for schools outreach: Generating awareness and interest in pharmacology in the younger generations
Ayoub, S., Cooper, Chelsey, Nunes, Fernando and Ruocco, Ray 2016. Construction of cell models for drug-receptor pharmacology activities for schools outreach: Generating awareness and interest in pharmacology in the younger generations. Pharmacology 2015. Queen Elizabeth Conference Centre, London 15 - 17 Dec 2015 pA2 Online British Pharmacological Society.
Characterisation of the signalling mechanisms involved in the induction of cyclooxygenase-2 by interleukin-4
Sivanjaa Manoj, Manoj, Morgan, W. and Ayoub, S. 2016. Characterisation of the signalling mechanisms involved in the induction of cyclooxygenase-2 by interleukin-4. PHARMACOLOGY 2016. The Queen Elizabeth II Conference Centre, London 13 - 15 Dec 2016 London British Pharmacological Society.