Fc-fusion mimetics

Article

Khalili, H., Khaw, P. T. and Brocchini, S. 2016. Fc-fusion mimetics. Biomaterials Science. 4 (6), pp. 943-947. https://doi.org/10.1039/C6BM00077K

Publication dates
Authors	Khalili, H., Khaw, P. T. and Brocchini, S.
Abstract	The Fc-fusion mimetic RpR 2 was prepared by disulfide bridging conjugation using a PEG in the place of the Fc. RpR 2 displayed higher affinity for VEGF than aflibercept caused primarily by a slower dissociation rate, which can prolong a drug at its site of action. RpRs have considerable potential for development as stable, organ specific therapeutics.
Journal	Biomaterials Science
Journal citation	4 (6), pp. 943-947
ISSN	2047-4849
	2047-4830
Year	2016
Publisher	Royal Society of Chemistry
Accepted author manuscript	Fc-fusion mimetics.pdf
Digital Object Identifier (DOI)	https://doi.org/10.1039/C6BM00077K
Print	29 Apr 2016
Publication process dates
Deposited	20 Oct 2016
Accepted	08 Apr 2016
Funder	National Institute of Health Research Biomedical Research Centre
	Moorfields Special Trustees
	Helen Hamlyn Trust
	Medical Research Council
	Fight For Sight
	Freemasons Grand Charity
	Engineering & Physical Sciences Research Council Centre for Innovative Manufacturing in Emergent Macromolecular Therapies

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