Typing African Relapsing Fever Spirochetes

Scott, Julie Christine and Wright, David Julian Maurice and Cutler, Sally J. (2005) ‘Typing African Relapsing Fever Spirochetes’, Emerging Infectious Diseases, 11(11), pp. 1722-1729.

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Relapsing fever Borrelia spp. challenge microbiologic typing because they possess segmented genomes that maintain essential genes on large linear plasmids. Antigenic variation further complicates typing. Intergenic spacer (IGS, between 16S–23S genes) heterogeneity provides resolution among Lyme disease–associated and some relapsing fever spirochetes. We used an IGS fragment for typing East African relapsing fever Borrelia spp. Borrelia recurrentis and their louse vectors showed 2 sequence types, while 4 B. duttonii and their tick vectors had 4 types. IGS typing was unable to discriminate between the tick- and louseborne forms of disease. B. crocidurae, also present in Africa, was clearly resolved from the B. recurrentis/B. duttonii complex. IGS analysis of ticks showed relapsing fever Borrelia spp. and a unique clade, distant from those associated with relapsing fever, possibly equivalent to a novel species in ticks from this region. Clinical significance of this spirochete is undetermined.

Item Type: Article
Additional Information: Citation: Scott, J.C., Wright, D.J.M., Cutler, S.J. (2005) ‘Typing African Relapsing Fever Spirochetes’ Emerging Infectious Diseases 11 (11) 1722-1729.
Divisions: Schools > Health, Sports and Bioscience, School of
Depositing User: Mr Stephen Grace
Date Deposited: 03 Aug 2010 14:34
Last Modified: 27 Sep 2012 12:00
URI: http://hdl.handle.net/10552/930

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